195. Back to Basics - Immunotherapy in Metastatic Colorectal Cancer

Podcast: Oncology for the Inquisitive Mind · Michael Fernando and Josh Hurwitz

Opublikowano: 2026-03-28

Historically, colorectal cancer treatment has been fairly standard, but this has shifted over the past decade with the introduction of targeted therapies. This week, our focus is on patients with microsatellite instability (dMMR) colorectal cancer, a small but meaningful cohort. This condition affects up to 15% of patients, many of whom carry germline mutations in the MLH1 and MSH2 genes, which simply means that cells can't recognise and fix spontaneous mutations. Historically, these cancers are less responsive to chemotherapy. This week, we explore two immunotherapy regimens - pembrolizumab, ipilimumab and nivolumab. Studies discussed in...