GLP-1 Maintenance: What Happens When You Lower Your Dose, Switch Medications, or Stop Entirely

Podcast: Docs Who Lift · Docs Who Lift

Opublikowano: 2026-05-25

Dr. Spencer Nadolsky and Karl break down two brand new randomized controlled trials that put hard numbers on a question they have been navigating clinically for years: what actually happens to patients on GLP-1 medicines when they try to lower their dose, switch to a cheaper option, or come off entirely. In this episode they cover why obesity biology actively fights back against weight loss through hunger hormones, fat cell hormones, and hypothalamic signaling in ways that make maintenance genuinely hard for most people and not a failure of willpower, what the Surmount-4 trial showed about weight...