Reversing Cellular Senescence: GPX4, Ferroptosis, and Adaptive Senotherapeutics with Dr. Frederick Beddingfield

Podcast: Beauty Bytes with Dr. Kay: Secrets of a Plastic Surgeon™ · Kay Durairaj, MD, FACS @beautybydrkay

Opublikowano: 2026-09-02

Are you fascinated by the molecular science of aging and senescence? In this episode of Beauty Bytes, I am joined by Dr. Frederick Beddingfield III, the CEO of Rubedo Life Sciences, a physician-scientist, and a former senior leader at Allergan. We focus on the cutting edge of longevity and how Rubedo is developing adaptive senotherapeutics to reverse cellular aging and extend healthspan. Dr. Beddingfield explains the science behind their lead drug, RLS 1496, which targets the enzyme glutathione peroxidase 4 (GPX4) to regulate ferroptosis, an iron-dependent cell death pathway. We discuss how this drug not only eliminates toxic senescent cells but a...