VS ACLS | Lidocaine v Amiodarone

Podcast: STAT Stitch Deep Dive Podcast Beyond The Bedside · Regular Guy

Opublikowano: 2026-09-22

80/20 Comparative Summary: Amiodarone vs. Lidocaine 1. Class & Mechanism of Action Amiodarone (Cordarone): Class III antiarrhythmic with Class I, II, III, and IV actions[1][2]. Primarily blocks potassium channels in phases 2 and 3, delaying repolarization and prolonging effective refractory period[1]. Weakly blocks sodium channels (phase 0 upstroke), depresses SA/AV automaticity, blocks calcium channels, noncompetitively inhibits alpha/beta receptors, and causes vasodilation[2][3].Lidocaine: Class IB antiarrhythmic and amide local anesthetic[4]. Selectively inhibits fast sodium channel influx in phase 0, shortening action potential duration and refractory period in His-Purkinje tissue while suppressing automaticity/reentry preferentially in ischemic myocardium[6]. Blocks nerve sodium channels for...